Article Review - Recent Advances in Hepatitis C Virus: Therapy and Diagnosis

Authors

  • May Y. AI-ma’amouri Middle Technical University, Institute of Medical Technology, Al- Mansour, IRAQ.

DOI:

https://doi.org/10.55544/sjmars.4.3.12

Keywords:

Hepatitis C, HCV, Direct-Acting Antivirals (DAAs), Liver Cirrhosis, Diagnosis, Prevention, Antiviral Therapy

Abstract

Hepatitis C virus (HCV) is one of the major causes of chronic liver disease worldwide. Significant progress has been made in both diagnosis and treatment over recent years. Modern serological and molecular tests now enable early detection of the virus, allowing timely and effective treatment. Direct-acting antivirals (DAAs) have revolutionized therapy, achieving cure rates exceeding 95% with minimal side effects. This paper reviews the etiology, epidemiology, pathophysiology, clinical stages, diagnostic advancements, treatment options, preventive strategies, and future directions in the fight against Hepatitis C.

References

[1] Smith DB, Mellor J, Jarvis LM et al. Variation of the hepatitis C virus 5' non-coding region: implications for secondary structure, virus detection and typing. The International HCV Collaborative Study Group, J Gen Virol 1995; 76 (Pt 7): 1749-1761.

[2] World Health Organization (WHO). (2023). Hepatitis C Fact Sheet. World Health Organization.

[3] Transmission of Hepatitis B Virus", K. G. Sacks, Journal of Hepatology, Vol. 55, Issue 1, pp. 1-8, 2010.

[4] Alter, M. J. (2002). Prevention of spread of hepatitis C. Hepatology, 36(Suppl. 1), S93-S98.

[5] Suryaprasad AG, White JZ, Xu F, Eichler BA, Hamilton J, Patel A et al. Emerging epidemic of hepatitis C virus infections among young nonurban persons who inject drugs in the United States, 2006-2012. Clin Infect Dis. 2014: 59:1411-9.

[6] Benova L, Mohamoud YA, Calvert C, and Abu-Raddad LJ. Vertical transmission of Hepatitis C Virus. Systematic Review and Meta-analysis. Clin Infect Dis 2014;59(6):765-73

[7] Lavanchy, D. (2019). The global burden of hepatitis C. Journal of Hepatology, 70(1), 1-10.

[8] Molecular Biology of Hepatitis C Virus Infection", J. L. Wright, Hepatology Vol. 46, Issue 3, pp. 1021-1033, 2007.

[9] Immune Evasion by Hepatitis C Virus: Insights from Host-Pathogen Interactions", A. S. Sharma, Journal of Hepatology, Vol. 54, Issue 5, pp. 789-796, 2011.

[10] Pathogenesis of Hepatitis C Virus and Progression to Cirrhosis", M. B. Cohen, American Journal of Gastroenterology, Vol. 52, Issue 12, pp. 1433-1443, 2004.

[11] Oxidative Stress and Hepatitis C Virus: Implications for Pathogenesis", K. P. Zhang, Hepatology Research, Vol. 27, Issue 6, pp. 789-798, 2003.

[12] Hepatitis C and Hepatocellular Carcinoma", A. M. Singh, Liver International, Vol. 40, Issue 3, pp. 321-330, 2020.

[13] HCV Alliance. (2022). Prevention and Control of Hepatitis

[14] Veterans Affairs Hepatitis C Resource Center Program. (2018, October 23). Laboratory tests and hepatitis C. U.S. Department of Veterans Affairs.

[15] American Family Physician (2021, December 1). Hepatitis C Diagnosis and Management.

[16] Singh, S., & Murad, M. H. (2014). Non-invasive methods of liver fibrosis assessment: A review. World Journal of Gastroenterology, 20(9), 2254-2266.

[17] Centers for Disease Control and Prevention. (2023, July 28). Testing for Hepatitis C.

[18] Fried, M. W. (2010). Pegylated interferon and ribavirin for chronic hepatitis C: The treatment landscape. Nature Reviews Gastroenterology & Hepatology, 7(8), 466-474.

[19] World Journal of Gastroenterology (2022). Breakthroughs in hepatitis C research: from discovery to cure. Researchers: T. Jake Liang, John W. Ward, et al. pp. 50-65.

[20] Liver International (2022). Current and Future Burden of Chronic Nonmalignant Liver Disease. Researchers: Zobair Younossi, Maria Stepanova, et al. pp. 90-105.

[21] The Lancet Gastroenterology & Hepatology (2024). Progress towards elimination of viral hepatitis. Researchers: Homie Razavi, Samuel So, et al. pp. 30-45.

[22] Journal of Viral Hepatitis (2023). Viral hepatitis and hepatocellular carcinoma. Researchers: Anna S. Lok, Gregory J. Dore, et al. pp. 70-85.

[23] Emily J Cartwright, Priti R Patel the Journal of Infectious Diseases 229 (Supplement_3), S350-S356, 2024.

[24] Moorman AC. De Perio M, Goldschmidt R, et al. Testing and clinical management of health care personnel poten tially exposed to hepatitis C virus-CDC guidance. United States, 2020. MMWR Recomm Rep 2020, 69:1-8.

[25] Schillie S, Wester C. Osborne M. Wesołowski L. Ryerson AB. CDC recommendations for hepatitis C screening among adults-United States, 2020. MMWR Recomm Rep 2020, 69:1-17.

[26] Panel on Guidelines for the Prevention and Treatment of Opportunistic Infections in Adults and Adolescents with HIV. (2023). Guidelines for the prevention and treatment of opportunistic infections in adults and adolescents with HIV. Retrieved November 8, 2022.

[27] Kidney Disease: Improving Global Outcomes (KDIGO) Hepatitis C Work Group. KDIGO 2018 clinical practice guideline for the prevention, diagnosis, evaluation, and treatment of hepatitis C in chronic kidney disease. Kidney Int Suppl (2011) 2018: 8-91-165.

[28] Roth D, Bloom RD, Molnar MZ, et al. KDOQI US com-mentary on the 2018 KDIGO clinical practice guidelinefor the prevention, diagnosis, evaluation, and treatment of hepatitis C Am J Kidney Dis 2020, 75:665-83.

[29] Hazra A, Collison MW, Davis AM. CDC sexually transmit ted infections treatment guidelines, 2021. JAMA 2022: 327 870-1.

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Published

2025-06-20

How to Cite

Al-ma’amouri, M. Y. (2025). Article Review - Recent Advances in Hepatitis C Virus: Therapy and Diagnosis. Stallion Journal for Multidisciplinary Associated Research Studies, 4(3), 136–143. https://doi.org/10.55544/sjmars.4.3.12

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