Serum Interleukin-6 and pro-B-type Natriuretic Peptide as Biomarkers

Abstract

Thyroid hormones have profound effects on the cardiovascular system, but the signature of the changes is not known to distinguish thyroid-induced cardiac stress from primary cardiac disease. This study aimed to assess the role of interleukin-6 (IL-6) and pro-B-type natriuretic peptide (proBNP) in addition to thyroid, metabolic and renal parameters in four clinical groups. This study iniclude 140 participants, 50 healthy controls and 30 with hyperthyroidism treated with carbimazole, 30 with heart disease, and 30 with hyperthyroidism and heart disease. Roche cobas c111 for glucose, lipid profile and renal functions, Mindray CL-900i for thyroid hormones and by ELISA method were used to measure the IL6 and ProBNP. ANOVA or Kruskal–Wallis test was used to analyse the data, correlation analysis and receiver operating characteristic (ROC) curves. Results: The level of IL-6 increased in a step-wise fashion and proBNP was significantly increased in both cardiac groups. proBNP was nearly as good at discriminating against heart disease alone as against combined disease (AUC 1.000), while IL-6 separated heart disease from combined disease (AUC 0.706, p = 0.002). In conclusion, thyroid and cardiac biomarker profiling when performed together is helpful in the recognition of cardiac involvement in thyroid disease.